Cancer Genomics

Identifying the genetic changes in a tumour that help match patients to targeted therapies and clinical trials.

Cancer Genomics

No two cancers are exactly alike. Patients with the same diagnosis can carry different genetic changes in their tumours, and those changes often determine which treatment will work best.

Cancer genomic testing identifies these changes directly in tumour tissue. The results help oncologists, pathologists and surgical teams match patients to targeted therapies and clinical trials.

Who This is For

For patients and families, and for the oncologists, pathologists and surgical teams who request tumour testing.

Questions and Indications

Targeted therapies act on a specific genetic alteration in the cancer. They are most effective when that alteration is present and offer little benefit when it is absent. International oncology guidelines recommend testing for actionable alterations in many advanced solid tumours before treatment is selected.

Testing many genes in a single assay, rather than one gene at a time, conserves limited biopsy tissue and shortens the time to a complete molecular result. One panel test can answer several clinical questions from one sample.

  • Non-small cell lung cancer: EGFR (including resistance mutations), ALK, ROS1, RET and NTRK fusions, BRAF, KRAS, ERBB2 (HER2), MET exon 14 skipping and amplification, NRG1 fusions.
  • Colorectal cancer: KRAS, NRAS, BRAF, ERBB2, PIK3CA, NTRK fusions.
  • Breast cancer: PIK3CA, AKT1, ESR1, ERBB2, PTEN.
  • Thyroid cancer: BRAF, RET, NTRK fusions, HRAS, NRAS.
  • Gastrointestinal stromal tumour (GIST): KIT, PDGFRA.
  • Melanoma: BRAF, NRAS, KIT, GNAQ, GNA11.
  • Cholangiocarcinoma: FGFR2 fusions, IDH1.
  • Bladder and urothelial cancer: FGFR3.
  • Prostate cancer: AR, including the AR-V7 splice variant.
  • Gliomas: IDH1, IDH2, EGFR (including EGFRvIII).
  • Any solid tumour: NTRK1, NTRK2 and NTRK3 fusions, which are targetable regardless of tumour origin.

Relevant Tests

Tests and pages for clinicians and healthcare professionals. Browse our portfolio of tests.

View All Tests

Solid Tumour Precision Panel (50 genes)

Targeted NGS of DNA and RNA from one tumour sample across 50 genes relevant to solid cancers, reported in 3 working days.

Sample FFPE tumour block or 8 to 10 unstained sections; at least 20% tumour content preferred
Turnaround 3 working days from receipt of a suitable sample
Method Targeted amplicon NGS of DNA and RNA on the Genexus System
Clinical Area Cancer Genomics

Counselling & Support

Tumour testing looks at changes in the cancer to guide treatment. When an inherited cancer risk is suspected, a genetic counsellor can explain what separate germline testing involves and what it may mean for relatives.